Endocrine Abstracts

Introduction: Immunologic background often present different association of two or more autoimmune diseases. However the coexistence of Basedow disease (BD) – the prototype of these disorders - with pernicious anemia (PA), sometimes as a component of pancytopenia, is rarely described. Between 50 patients operated on immunologic hyperthyroidism in a 20 years period only one case related this uncommon combination.Case report: AB, a 46-year-old woman w...

Background: Parathyroid adenomas represent the most common anatomoclinical variety of hyperparathyroidism.Material and method: From our experience of 84 cases of hyperparathyroidism – 20 primary and 64 ‘renal’ (CKD-MBD) – 18 patients underwent surgery for solitary adenomas of these glands. Clinical data, laboratory and imaging test results, surgical procedures and outcome were comprehensively analysed.Results: W...

Introduction: Multiple endocrine neoplasia type 1 (MEN1) is an autosomal dominant disorder consisting in the development of primary hyperparathyroidism (PHPT), pancreatic neuroendocrine tumors, and pituitary adenomas. Occurrence of glucagonoma in MEN1 patients is rare (3%) and metastatic disease is present in 50% to 80% of patients at the time of diagnosis. The association of adrenal nodules/tumors and MEN1 is also rare.Case report: We present the case o...

Introduction: A glucagonoma is a rare neuroendocrine tumor that originates almost exclusively in the pancreas and probably accounts for 1% of all neuroendocrine tumors. MEN11 is characterized by the development of primary hyperparathyroidism (PHPT), pancreatic neuroendocrine tumors and pituitary adenomas.Methods: We present the case of a 39-year-old female, with history of type 2 diabetes mellitus and hypokalemia2 who presented to t...

Infertility affects milions of couples worldwide. Determining the exact cause represents a real challenge and may require a complex work-up.Objective: To asses the main etiological factors of female infertility and the best treatment.Methods: Retrospective study which included 150 women diagnosed with infertility in a Romanian tertiary center. The median age was 30.5 years (20–41), 65.3% (n=98) of the patients were di...

A 28 year old female with no significant medical history, 25 weeks into her second pregnancy was referred to endocrinology with adjusted calcium of 2.99 mmol/l. She had a short history of generalised aches and tiredness. Examination did not reveal any stigmata of MEN1 or the HPT-JT syndromes. There was no known family history of endocrine disorders. Her PTH was 7 pmol/l, confirming primary hyperparathyroidism. As parathyroid Tc-scintigraphy would be contraindicated in pregnanc...

Background: The quoted risk of morbidity after thyroidectomy is based on published data from large series but patients’ perception remains insufficiently explored.Methods: A standardized questionnaire was mailed to 312 patients who underwent thyroid surgery in a large university hospital between Jan2008–Dec2010.Results: Replies were received from 202(64%) patients (56M:166F, age 55±16 yrs) at median 23 months after l...

Background: Papillary thyroid cancer (PTC) metastasizes to central compartment lymph nodes (CCLN) in majority of patients. Such metastases are associated with high risk of locoregional recurrence and distant metastasis. Only one study has investigated the relation between the number of metastatic CCLN and prognosis (Soon Lee et al. 2010 WJS). This study evaluated the clinical implication of the number of metastatic CCLN in PTC.Methods: Between Jan...

Introduction: The Birt–Hogg–Dube syndrome (BHDS) is a rare autosomal dominant genodermatosis characterised by presence of at least one of the following: benign skin fibrofolliculomas, lung cysts with recurrent pneumothoraces or renal tumours. The phenotypic constellation is due to heterozygous germline mutations of the tumour suppressor gene – FLCN, located on 17p11.2, encoding a 579 aminoacid protein termed folliculin. Case reports have described endocrine tumo...

Background: Length-of-stay (LOS) after various surgical procedures varies greatly between centres and countries. In the US there is increasing tendency towards day-case thyroid and parathyroid surgery but their model of care cannot be easily extrapolated. In the UK the average LOS for such operations is 3–4 days.Methods: Retrospective review of data retrieved from hospital-based software regarding the surgical activity during a decade in a large Uni...